Blood pyruvate in vitamin B1 deficiency

Lxxx. Blood Pyruvate in Vitamin B1 Deficiency

IN the course of recent work on the role of vitamin B, in the metabolism of brain, it was discovered [Peters and Sinclair, 1933] that lactate solutions in which avitaminous pigeon's brain cells had respired for 2 hours gave a positive nitroprusside reaction for pyruvic acid [Simon and Piaux, 1924]. This led to a quantitative investigation of the formation of pyruvic acid during the respiration ...

Vitamin-B1 Deficiency

Clxxxviii. Studies on the Metabolism of Pyruvic Acid in Normal and Vitamin B1-deficient States v. the Effect of Exercise on Blood Pyruvate in Vitamin B1 Deficiency in Man

FOLLOWING the establishment [Platt & Lu, 1939] of the occurrence of increased amounts of pyruvic acid in the body fluids of patients suffering from beri-beri and the studies of Lu [1939] on the effect of muscular activity on the blood pyruvate of the rabbit, it appeared desirable that an investigation should be made of the relationships between pyruvic acid accumulation in the blood, amount of ...

Cclxxxiii. the Estimation of Vitamin B1 in Blood

MEIKLEJOHN [1937] has described a method, based upon the work of Schopfer [1935], of estimating vitamin B1 in "small samples" (15 ml.) of blood. From his evidence he concludes "that the method... provides a quantitative estimate of the true vitamin B1 content of the blood". Since a clinical test for vitamin B1 in blood is badly needed, and since Meiklejohn's method is being used by several work...

Vitamin B1

Vitamin B1 is a watersoluble vitamin. It consists out of a pyrimidineand a thiazol ring, which are synthesized independently and linked afterwards.Vitamin B1 is de novo produced by many plants and microorganisms. Humans and animals have to take it up by nutrition. They are only able to do the phosphorylation reaction of the thiamin molecule. Thiamin is found free and as mono-, diand triphosphat...